国外病理信息侦探
← 返回首页前列腺 / 泌尿生殖

淋巴上皮瘤样亚型尿路上皮癌：合体样生长、炎症背景与鉴别要点Lymphoepithelioma-like subtype of urothelial carcinoma: syncytial growth, inflammation, and differential tips

2026-11-08 · X · @slusagar · 教学短帖
导读
  • 淋巴上皮瘤样（LEL）亚型尿路上皮癌：合体样生长伴混杂炎症；纯型时预后可较好且可能对化疗有反应。
  • 与鼻咽淋巴上皮瘤样癌不同，尿路上皮 LEL 亚型与 EBV 无关；分子上常呈基底样表型。
  • 镜下鉴别：淋巴瘤、小细胞癌、良性炎症——合体样上皮巢 + 合适 IHC 是关键。
  • 本站收录 @slusagar 公开教学帖要点与 4 张 HE 附图（原帖无图注，图注按所见简述）。

收录范围：作者 X 公开帖文字要点中英对照，以及帖内 4 张 HE 附图。非期刊论著全文。

教学要点

Ankur Sangoi（@slusagar）于 2026-11-07 发帖，归纳淋巴上皮瘤样亚型尿路上皮癌（#GUpath）要点：

  • 镜下：合体样（syncytial）生长 + 混杂炎症。
  • 预后/治疗：尤其当成分为纯型时，预后可较好，且可能对化疗有反应。
  • 病因：与 EBV 无关（不同于经典鼻咽淋巴上皮瘤样癌）。
  • 分子：常呈基底样（basal-like）分子表型。
  • 鉴别诊断：淋巴瘤、小细胞癌、良性炎症。

附图

原帖附 4 张 HE 图，未给图注；以下图注按图像所见简述。

淋巴上皮瘤样尿路上皮癌：低至中倍，合体样上皮巢伴密集淋巴样间质
图 1　低至中倍：合体样上皮巢埋于密集淋巴样间质中。来源：Ankur Sangoi 的 X 帖附图；原帖未附图注。
中倍：合体样生长与炎症背景
图 2　中倍：合体样生长伴显著炎症浸润。来源同上；原帖未附图注。
更高倍：合体样上皮细胞与炎症细胞交错
图 3　更高倍：上皮与炎症细胞交错。来源同上；原帖未附图注。
高倍：上皮细胞境界不清、核仁可见，间质炎症显著
图 4　高倍：上皮细胞境界不清、核仁可见，炎症背景显著。来源同上；原帖未附图注。
In brief
  • Lymphoepithelioma-like (LEL) subtype urothelial carcinoma: syncytial growth with admixed inflammation; pure forms may have favorable prognosis and chemo response.
  • Unlike nasopharyngeal LEL carcinoma, the urothelial LEL subtype is not EBV-related and often shows a basal-like molecular phenotype.
  • DDx: lymphoma, small cell carcinoma, benign inflammation — syncytial epithelial nests plus appropriate IHC are key.
  • This post captures @slusagar's public teaching tip and four H&E images (no legends in the original post; captions briefly describe what is shown).

Scope: bilingual rendering of the author's public X teaching tip, plus the four attached H&E images. Not a journal full-text article.

Teaching points

Ankur Sangoi (@slusagar) posted on 2026-11-07 with these #GUpath tips on the lymphoepithelioma-like subtype of urothelial carcinoma:

  • Morphology: syncytial growth + admixed inflammation.
  • Prognosis/therapy: may show favorable prognosis (especially when pure) and respond to chemotherapy.
  • Etiology: not related to EBV.
  • Molecular: basal-like molecular phenotype.
  • Differential diagnosis: lymphoma, small cell carcinoma, benign inflammation.

Images

Four H&E images were attached; no legends were provided. Captions below briefly describe what is shown.

LEL urothelial carcinoma: low–medium power syncytial epithelial nests with dense lymphoid stroma
Image 1. Low–medium power: syncytial epithelial nests in a dense lymphoid stroma. Source: image from Ankur Sangoi's X post; no legend in the post.
Medium power: syncytial growth in an inflammatory background
Image 2. Medium power: syncytial growth with prominent inflammation. Same source; no legend in the post.
Higher power: syncytial epithelial cells intermingled with inflammatory cells
Image 3. Higher power: epithelial and inflammatory cells intermingled. Same source; no legend in the post.
High power: poorly demarcated epithelial cells with visible nucleoli and prominent stromal inflammation
Image 4. High power: poorly demarcated epithelial cells with visible nucleoli and a brisk inflammatory background. Same source; no legend in the post.

原文信息

中文标题淋巴上皮瘤样亚型尿路上皮癌：合体样生长、炎症背景与鉴别要点
原文标题Lymphoepithelioma-like subtype of urothelial carcinoma (X teaching tip)
来源X · @slusagar（Ankur Sangoi, MD）
本站发布2026-11-08
原文日期2026-11-07（X 发帖，UTC；Asia/Shanghai 为 11-07 上午）
作者Ankur Sangoi
原文链接X 原帖
全文与采集范围X 教学短帖文字 + 4 张 HE 附图。
标签前列腺 / 泌尿生殖

版权

配图与文字来自作者 X 公开帖，版权归原作者；中文整理供学习参考。